2,3 The current “gold standard” imaging technique for atherosclerosis is x-ray contrast angiography, which provides high-resolution definition of the site and severity of luminal stenoses, but no information about plaque inflammation. 1 Plaques containing numerous inflammatory cells, in particular macrophages, have a high risk of rupture, whereas those with few inflammatory cells are at lower risk. Inflammation is important in both the pathogenesis and outcome of atherosclerosis. Autoradiography of excised plaques confirmed accumulation of deoxyglucose in macrophage-rich areas of the plaque.Ĭonclusions- This study demonstrates that atherosclerotic plaque inflammation can be imaged with 18FDG-PET, and that symptomatic, unstable plaques accumulate more 18FDG than asymptomatic lesions. There was no measurable 18FDG uptake into normal carotid arteries. The estimated net 18FDG accumulation rate (plaque/integral plasma) in symptomatic lesions was 27% higher than in contralateral asymptomatic lesions. Symptomatic carotid plaques were visible in 18FDG-PET images acquired 3 hours post- 18FDG injection. Methods and Results- Eight patients with symptomatic carotid atherosclerosis were imaged using 18FDG-PET and co-registered CT. In this study we tested whether 18FDG-PET imaging can identify inflammation within carotid artery atherosclerotic plaques.
The glucose analogue -fluorodeoxyglucose ( 18FDG) can be used to image inflammatory cell activity non-invasively by PET. Current imaging techniques provide anatomic data but no indication of plaque inflammation. Customer Service and Ordering Informationīackground- Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.
Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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